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1

Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry

Toshiyuki Fukao, Gary D. Lopaschuk, Grant A. Mitchell

Journal:

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

2

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

Timothy R. Koves, John R. Ussher, Robert C. Noland, Dorothy Slentz, Merrie Mosedale, Olga Ilkayeva, James Bain, Robert Stevens, Jason R.B. Dyck, Christopher B. Newgard, Gary D. Lopaschuk, Deborah M. M

Journal:

Cell Metabolism

Year:

2008

Language:

english

File:

PDF, 1.00 MB

english, 2008

3

Acetyl-CoA carboxylase control of fatty acid oxidation in hearts from hibernating Richardson's ground squirrels

Darrell D Belke, Lawrence C.H Wang, Gary D Lopaschuk

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1998

Language:

english

File:

PDF, 238 KB

english, 1998

4

Postresuscitation Cyclosporine Treatment Attenuates Myocardial and Cardiac Mitochondrial Injury in Newborn Piglets with Asphyxia-Reoxygenation*

Gill, Richdeep S., Lee, Tze-Fun, Manouchehri, Namdar, Liu, Jiang-Qin, Lopaschuk, Gary, Bigam, David L., Cheung, Po-Yin

Journal:

Critical Care Medicine

Year:

2013

Language:

english

File:

PDF, 6.59 MB

english, 2013

5

Metabolic Modulators in Heart Disease: Past, Present, and Future

Lopaschuk, Gary D.

Journal:

Canadian Journal of Cardiology

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

6

Recovery of glycolysis and oxidative metabolism during postischemic reperfusion of hypertrophied rat hearts

Schonekess, B. O., Allard, M. F., Lopaschuk, G. D.

Journal:

American journal of physiology. Heart and circulatory physiology

Year:

1996

Language:

english

File:

PDF, 1.95 MB

english, 1996

7

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency

Ho, Kim L, Zhang, Liyan, Wagg, Cory, Batran, Rami Al, Gopal, Keshav, Levasseur, Jody, Leone, Teresa, Dyck, Jason R B, Ussher, John R, Muoio, Deborah M, Kelly, Daniel P, Lopaschuk, Gary D

Journal:

Cardiovascular Research

Year:

2019

Language:

english

File:

PDF, 932 KB

english, 2019

8

Weight Loss Enhances Cardiac Energy Metabolism and Function in Heart Failure Associated with Obesity

Karwi, Qutuba G, Zhang, Liyan, Altamimi, Tariq R, Wagg, Cory S, Patel, Vaibhav, Uddin, Golam M, Joerg, Alice R, Padwal, Raj S, Johnstone, David E, Sharma, Arya, Oudit, Gavin Y, Lopaschuk, Gary D

Journal:

Diabetes, Obesity and Metabolism

Year:

2019

Language:

english

File:

PDF, 1.75 MB

english, 2019

9

Ketone metabolism in the failing heart

Lopaschuk, Gary D., Karwi, Qutuba G., Ho, Kim L., Pherwani, Simran, Ketema, Ezra B.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2020

File:

PDF, 3.20 MB

2020

10

Analysis of Myocardial Plasmalogen and Diacyl Phospholipids and Their Arachidonic Acid Content Using High-Performance Liquid Chromatography

R. Schulz, K.D. Strynadka, D.L. Panas, P.M. Olley, G.D. Lopaschuk

Journal:

Analytical Biochemistry

Year:

1993

File:

PDF, 653 KB

1993

11

Metabolic remodeling associated with subchronic doxorubicin cardiomyopathy

Rui A. Carvalho, Rui P.B. Sousa, Virgilio J.J. Cadete, Gary D. Lopaschuk, Carlos M.M. Palmeira, James A. Bjork, Kendall B. Wallace

Journal:

Year:

2010

Language:

english

File:

PDF, 844 KB

english, 2010

12

Advantages and limitations of experimental techniques used to measure cardiac energy metabolism

Gary D Lopaschuk

Journal:

Journal of Nuclear Cardiology

Year:

1997

Language:

english

File:

PDF, 1.31 MB

english, 1997

13

Glucose oxidation is stimulated in reperfused ischemic hearts with the carnitine palmitoyltransferase 1 inhibitor, Etomoxir

Gary D. Lopaschuk, Gordon F. McNeil, Jeffrey J. McVeigh

Journal:

Molecular and Cellular Biochemistry

Year:

1989

Language:

english

File:

PDF, 392 KB

english, 1989

14

The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia

Gary D. Lopaschuk, Maruf Saddik

Journal:

Molecular and Cellular Biochemistry

Year:

1992

Language:

english

File:

PDF, 518 KB

english, 1992

15

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy:resuscitating the hibernating right ventricle

Lin Piao, Yong-Hu Fang, Virgilio J. J. Cadete, Christian Wietholt, Dalia Urboniene, Peter T. Toth, Glenn Marsboom, Hannah J. Zhang, Idith Haber, Jalees Rehman, Gary D. Lopaschuk, Stephen L. Archer

Journal:

Journal of Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 815 KB

english, 2010

16

α-Lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts

A. Onay-Besikci, C. Wagg, T. P. Lopaschuk, W. Keung, G. D. Lopaschuk

Journal:

Basic Research in Cardiology

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

17

Targeting malonyl CoA inhibition of mitochondrial fatty acid uptake as an approach to treat cardiac ischemia/reperfusion

John R. Ussher, Gary D. Lopaschuk

Journal:

Basic Research in Cardiology

Year:

2009

Language:

english

File:

PDF, 226 KB

english, 2009

18

The isolated working mouse heart: methodological considerations

T. S. Larsen, Darrell D. Belke, Rozsa Sas, Wayne R. Giles, David L. Severson, Gary D. Lopaschuk, John V. Tyberg

Journal:

Pflügers Archiv European Journal of Physiology

Year:

1999

Language:

english

File:

PDF, 144 KB

english, 1999

19

Malonyl-CoA Decarboxylase Inhibition as a Novel Approach to Treat Ischemic Heart Disease

Gary D. Lopaschuk, William C. Stanley

Journal:

Cardiovascular Drugs and Therapy

Year:

2006

Language:

english

File:

PDF, 329 KB

english, 2006

20

Proteomic analysis of cardiac metabolic enzymes in asphyxiated newborn piglets

Justyna Fert-Bober, Grzegorz Sawicki, Gary D. Lopaschuk, Po-Yin Cheung

Journal:

Molecular and Cellular Biochemistry

Year:

2008

Language:

english

File:

PDF, 325 KB

english, 2008

21

Fatty acid oxidation inhibitors in the management of chronic complications of atherosclerosis

Clifford D. L. Folmes, Alexander S. Clanachan, Gary D. Lopaschuk

Journal:

Current Atherosclerosis Reports

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

22

Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5′AMP-activated protein kinase (AMPK) : Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique

Nandakumar Sambandam, Michael Steinmetz, Angel Chu, Judith Y. Altarejos, Jason R. B. Dyck, Gary D. Lopaschuk

Journal:

Year:

2004

Language:

english

File:

PDF, 244 KB

english, 2004

23

AMP-activated protein kinase control of energy metabolism in the ischemic heart

Journal:

International Journal of Obesity

Year:

2008

Language:

english

File:

PDF, 111 KB

english, 2008

24

KATP-channel activation: effects on myocardial recovery from ischaemia and role in the cardioprotective response to adenosine A1-receptor stimulation

William R Ford, Gary D Lopaschuk, Richard Schulz, Alexander S Clanachan

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 345 KB

english, 1998

25

Alteration of glycogen and glucose metabolism in ischaemic and post-ischaemic working rat hearts by adenosine A1 receptor stimulation

Heather Fraser, Gary D Lopaschuk, Alexander S Clanachan

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 197 KB

english, 1999

26

Influence of β-adrenoceptor tone on the cardioprotective efficacy of adenosine A1 receptor activation in isolated working rat hearts

William R Ford, Bodh I Jugdutt, Gary D Lopaschuk, Rick Schulz, Alexander S Clanachan

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 169 KB

english, 2000

27

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Jason R. B. Dyck, Gary D. Lopaschuk

Journal:

The Journal of Physiology

Year:

2006

Language:

english

File:

PDF, 543 KB

english, 2006

28

Maturation of fatty acid and carbohydrate metabolism in the newborn heart

A-Olufemi Makinde, Paul F. Kantor, Gary D. Lopaschuk

Journal:

Molecular and Cellular Biochemistry

Year:

1998

Language:

english

File:

PDF, 82 KB

english, 1998

29

Measurements of fatty acid and carbohydrate metabolism in te isolated working rat heart

Gary D. Lopaschuk, Rick L. Barr

Journal:

Molecular and Cellular Biochemistry

Year:

1997

Language:

english

File:

PDF, 222 KB

english, 1997

30

Glucose metabolism, H+production and Na+/H+- exchanger mRNA levels in ischemic hearts from diabetic rats

Jason R.B. Dyck, Gary D. Lopaschuk

Journal:

Molecular and Cellular Biochemistry

Year:

1998

Language:

english

File:

PDF, 256 KB

english, 1998

31

Metabolic Abnormalities in the Diabetic Heart

Gary D. Lopaschuk

Journal:

Heart Failure Reviews

Year:

2002

Language:

english

File:

PDF, 456 KB

english, 2002

32

Energy Metabolism in the Hypertrophied Heart

Nandakumar Sambandam, Gary D. Lopaschuk, Roger W. Brownsey, Michael F. Allard

Journal:

Heart Failure Reviews

Year:

2002

Language:

english

File:

PDF, 533 KB

english, 2002

33

The presence and binding characteristics of calmodulin in microsomal preparations enriched in sarcoplasmic reticulum from rabbit skeletal muscle

Barry Eibschutz, Allan P.G. Wong, Gary D. Lopaschuk, Sidney Katz

Journal:

Year:

1984

Language:

english

File:

PDF, 669 KB

english, 1984

34

Effects of High Intensity Exercise on Biventricular Function Assessed by Cardiac Magnetic Resonance Imaging in Endurance Trained and Normally Active Individuals

Jessica M. Scott, Ben T. Esch, Mark J. Haykowsky, Ian Paterson, Darren E.R. Warburton, Kelvin Chow, June Cheng Baron, Gary D. Lopaschuk, Richard B. Thompson

Journal:

The American Journal of Cardiology

Year:

2010

Language:

english

File:

PDF, 783 KB

english, 2010

35

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

Jagdip S. Jaswal, Wendy Keung, Wei Wang, John R. Ussher, Gary D. Lopaschuk

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

36

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Sébastien Bonnet, Stephen L. Archer, Joan Allalunis-Turner, Alois Haromy, Christian Beaulieu, Richard Thompson, Christopher T. Lee, Gary D. Lopaschuk, Lakshmi Puttagunta, Sandra Bonnet, Gwyneth Harry,

Journal:

Year:

2007

Language:

english

File:

PDF, 2.56 MB

english, 2007

37

Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding

Liyan Zhang, Jun Mori, Cory Wagg, Gary D. Lopaschuk

Journal:

Year:

2012

Language:

english

File:

PDF, 954 KB

english, 2012

38

Alterations in Fatty Acid Oxidation During Reperfusion of the Heart After Myocardial Ischemia

Gary D. Lopaschuk, PhD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 258 KB

english, 1997

39

Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism

Gary D Lopaschuk

Journal:

The American Journal of Cardiology

Year:

1998

Language:

english

File:

PDF, 74 KB

english, 1998

40

Methodology for measuring in vitro/ex vivo cardiac energy metabolism

Rick L Barr, Gary D Lopaschuk

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2000

Language:

english

File:

PDF, 334 KB

english, 2000

41

Direct measurement of energy metabolism in the isolated working rat heart

Rick L. Barr, Gary D. Lopaschuk

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1997

Language:

english

File:

PDF, 888 KB

english, 1997

42

Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5′-AMP activated protein kinase

Jason R. B. Dyck, Naomi Kudo, Amy J. Barr, Stephen P. Davies, D. Grahame Hardie, Gary D. Lopaschuk

Journal:

Year:

1999

Language:

english

File:

PDF, 424 KB

english, 1999

43

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2

Virgilio J. J. Cadete, Jolanta Sawicka, Jagdip S. Jaswal, Gary D. Lopaschuk, Richard Schulz, Danuta Szczesna-Cordary, Grzegorz Sawicki

Journal:

Year:

2012

Language:

english

File:

PDF, 451 KB

english, 2012

44

Novel O-palmitolylated beta-E1 subunit of pyruvate dehydrogenase is phosphorylated during ischemia/reperfusion injury

Clifford DL Folmes, Grzegorz Sawicki, Virgilio JJ Cadete, Grant Masson, Amy J Barr, Gary D Lopaschuk

Journal:

Proteome Science

Year:

2010

Language:

english

File:

PDF, 1.72 MB

english, 2010

45

Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia

Barry A. Finegan, Gary D. Lopaschuk, Manoj Gandhi, Alexander S. Clanachan

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 2.00 MB

english, 1996

46

Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts

LN Axelsen, W Keung, HD Pedersen, E Meier, D Riber, AL Kjølbye, JS Petersen, SD Proctor, N-H Holstein-Rathlou, GD Lopaschuk

Journal:

British Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.41 MB

english, 2012

47

Rat Heart Fatty Acid-Binding Protein Content Is Increased in Experimental Diabetes

J.F.C. Glatz, E. Vanbreda, H.A. Keizer, Y.F. Dejong, J.R.T. Lakey, R.V. Rajotte, A. Thompson, G.J. Vandervusse, G.D. Lopaschuk

Journal:

Biochemical and Biophysical Research Communications

Year:

1994

File:

PDF, 448 KB

1994

48

Improved Rat Heart Function after Low Ca2+ Perfused Preservation at 5°C for 18 Hours

Bin Liu, Gary D. Lopaschuk, Lawrence C.H. Wang

Journal:

Year:

1994

File:

PDF, 371 KB

1994

49

Calcium Improves Mechanical Function and Carbohydrate Metabolism Following Ischemia in Isolated Bi-ventricular Working Hearts From Immature Rabbits

Toshiyuki Itoi, Gary D. Lopaschuk

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1996

Language:

english

File:

PDF, 202 KB

english, 1996

50

Glucose Utilization and Glycogen Turnover are Accelerated in Hypertrophied Rat Hearts During Severe Low-flow Ischemia

Richard B. Wambolt, Sarah L. Henning, Dean R. English, Yulia Dyachkova, Gary D. Lopaschuk, Michael F. Allard

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1999

Language:

english

File:

PDF, 187 KB

english, 1999